Neuronal synchrony abnormalities associated with subclinical epileptiform activity in early-onset Alzheimer's disease.

ABSTRACT: Since the first demonstrations of network hyperexcitability in scientific models of Alzheimer's disease, a growing body of clinical studies have identified subclinical epileptiform activity and associated cognitive decline in patients with Alzheimer's disease. An obvious problem presented in these studies is lack of sensitive measures to detect and quantify network hyperexcitability in human subjects. In this study we examined whether altered neuronal synchrony can be a surrogate marker to quantify network hyperexcitability in patients with Alzheimer's disease. Using magnetoencephalography (MEG) at rest, we studied 30 Alzheimer's disease patients without subclinical epileptiform activity, 20 Alzheimer's disease patients with subclinical epileptiform activity and 35 age-matched controls. Pr

SUBMITTER: Ranasinghe KG 

PROVIDER: S-EPMC9630715 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature