Normative intracranial EEG maps epileptogenic tissues in focal epilepsy.

ABSTRACT: Planning surgery for patients with medically refractory epilepsy often requires recording seizures using intracranial EEG. Quantitative measures derived from interictal intracranial EEG yield potentially appealing biomarkers to guide these surgical procedures; however, their utility is limited by the sparsity of electrode implantation as well as the normal confounds of spatiotemporally varying neural activity and connectivity. We propose that comparing intracranial EEG recordings to a normative atlas of intracranial EEG activity and connectivity can reliably map abnormal regions, identify targets for invasive treatment and increase our understanding of human epilepsy. Merging data from the Penn Epilepsy Center and a public database from the Montreal Neurological Institute, we aggregated in

SUBMITTER: Bernabei JM 

PROVIDER: S-EPMC9630716 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature