Online MR guided dose escalated radiotherapy for organ preservation in distal rectal cancer.

ABSTRACT:

Introduction

Non-surgical management of rectal cancer aiming for organ-preservation is an important development to improve rectal cancer treatment. Dose escalated radiotherapy represents one approach to increase clinical complete response (cCR) rates. In the present study we present feasibility and outcome data on rectal cancer patients who were treated with dose escalated radiotherapy using an MR guided online response-adaptive workflow.

Material and methods

A total of five patients were treated with 45 Gy in 25 fractions to the mesorectum and the internal iliac lymph nodes and a simultaneous integrated boost to the primary tumor with 50 Gy in 25 fractions on a conventional linac. In addition, weekly response-adaptive boost fractions with 3 Gy per fraction were scheduled on

SUBMITTER: Boeke S 

PROVIDER: S-EPMC9630771 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature