Aspirin for Primary and Secondary Prevention of Mortality, Cardiovascular Disease, and Kidney Failure in the Chronic Renal Insufficiency Cohort (CRIC) Study.

ABSTRACT:

Rationale and objective

Chronic kidney disease is a risk enhancing factor for cardiovascular disease (CVD) and mortality, and the role of aspirin use is unclear in this population. We investigated the risk and benefits of aspirin use in primary and secondary prevention of CVD in the Chronic Renal Insufficiency Cohort Study.

Study design

Prospective observational cohort.

Setting & participants

3,664 Chronic Renal Insufficiency Cohort participants.

Exposure

Aspirin use in patients with and without preexisting CVD.

Outcomes

Mortality, composite and individual CVD events (myocardial infarction, stroke, and peripheral arterial disease), kidney failure (dialysis and transplant), and major bleeding.

Analytical approach

Intention-to-treat analysis and mul

SUBMITTER: Taliercio JJ 

PROVIDER: S-EPMC9630782 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature