Immunosuppression Exposure and Risk of Infection-Related Acute Care Events in Patients With Glomerular Disease: An Observational Cohort Study.

ABSTRACT:

Rationale & objective

Infections cause morbidity and mortality in patients with glomerular disease. The relative contributions from immunosuppression exposure and glomerular disease activity to infection risk are not well characterized. To address this unmet need, we characterized the relationship between time-varying combinations of immunosuppressant exposure and infection-related acute care events while controlling for disease activity, among individuals with glomerular disease.

Study design

Prospective, multicenter, observational cohort study.

Setting & participants

Adults and children with biopsy-proven minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or immunoglobulin A nephropathy/vasculitis were enrolled at 71 clinical sites i

SUBMITTER: Glenn DA 

PROVIDER: S-EPMC9630793 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature