Zinc supplement use and risk of aggressive prostate cancer: a 30-year follow-up study.

ABSTRACT:

Background

Zinc supplementation was hypothesized to have therapeutic potential against prostate cancer, but its influence on prostate cancer incidence especially at high doses is controversial.

Methods

A total of 47,240 men from the Health Professionals Follow-up Study were followed from 1986 to 2016. Men reported their zinc supplement use at baseline and biennially thereafter. Clinical features of prostate cancer included stage, grade, lethal and aggressive (T4 or N1 or M1 or Gleason 8-10) outcome. Multivariable Cox proportional hazards models were used to evaluate the association between zinc supplement use and incidence of prostate cancer.

Results

During a median follow-up of 28.3 years, we documented 6,980 incident prostate cancer cases including 1,053 lethal and

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9630799 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature