IL6 gene polymorphism association with calcific aortic valve stenosis and influence on serum levels of interleukin-6.

ABSTRACT: Aortic valve stenosis is the most frequent valve disease in developed countries and its prevalence will increase with population aging. There is still no pharmaceutical treatment nor biomarker to determine the susceptibility to develop aortic stenosis. Therefore, we analyzed the association of polymorphisms in risk loci with calcific aortic stenosis. Patients with aortic valve disease were genotyped for PALMD rs6702619, LPA rs10455872, and IL6 rs1800795 polymorphisms and circulating levels of interleukin-6 (IL-6) were measured. Calcium content of leaflets obtained in valve replacement surgeries was determined by micro-computed tomography. In the genotyping of 578 individuals, we found significant association between PALMD and IL6 polymorphisms and aortic

SUBMITTER: Junco-Vicente A 

PROVIDER: S-EPMC9630837 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature