Pan-cancer analyses of classical protein tyrosine phosphatases and phosphatase-targeted therapy in cancer.

ABSTRACT: Protein tyrosine phosphatases function in dephosphorylating target proteins to regulate signaling pathways that control a broad spectrum of fundamental physiological and pathological processes. Detailed knowledge concerning the roles of classical PTPs in human cancer merits in-depth investigation. We comprehensively analyzed the regulatory mechanisms and clinical relevance of classical PTPs in more than 9000 tumor patients across 33 types of cancer. The independent datasets and functional experiments were employed to validate our findings. We exhibited the extensive dysregulation of classical PTPs and constructed the gene regulatory network in human cancer. Moreover, we characterized the correlation of classical PTPs with both drug-resistant and drug-sensitive responses to anti-cancer drug

SUBMITTER: Wang T 

PROVIDER: S-EPMC9630847 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature