A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia.

ABSTRACT: Apathy and disinhibition are common and highly distressing neuropsychiatric symptoms associated with negative outcomes in persons with dementia. This paper is a critical review of functional and structural neuroimaging studies of these symptoms transdiagnostically in dementia of the Alzheimer type, which is characterized by prominent amnesia early in the disease course, and behavioural variant frontotemporal dementia, characterized by early social-comportmental deficits. We describe the prevalence and clinical correlates of these symptoms and describe methodological issues, including difficulties with symptom definition and different measurement instruments. We highlight the heterogeneity of findings, noting however, a striking similarity of the set of brain regions implicated across clini

SUBMITTER: Jenkins LM 

PROVIDER: S-EPMC9630876 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature