Characterization of diet-dependent temporal changes in circulating short-chain fatty acid concentrations: A randomized crossover dietary trial.

ABSTRACT:

Background

Production of SCFAs from food is a complex and dynamic saccharolytic fermentation process mediated by both human and gut microbial factors. Knowledge of SCFA production and of the relation between SCFA profiles and dietary patterns is lacking.

Objectives

Temporal changes in SCFA concentrations in response to 2 contrasting diets were investigated using a novel GC-MS method.

Methods

Samples were obtained from a randomized, controlled, crossover trial designed to characterize the metabolic response to 4 diets. Participants (n = 19) undertook these diets during an inpatient stay (of 72 h). Serum samples were collected 2 h after breakfast (AB), after lunch (AL), and after dinner (AD) on day 3, and a fasting sample (FA) was obtained on day 4. The 24-h urine sampl

SUBMITTER: Brignardello J 

PROVIDER: S-EPMC9630877 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature