Respiratory Microbiome Disruption and Risk for Ventilator-Associated Lower Respiratory Tract Infection.

ABSTRACT:

Background

Ventilator-associated lower respiratory tract infection (VA-LRTI) is common among critically ill patients and has been associated with increased morbidity and mortality. In acute critical illness, respiratory microbiome disruption indices (MDIs) have been shown to predict risk for VA-LRTI, but their utility beyond the first days of critical illness is unknown. We sought to characterize how MDIs previously shown to predict VA-LRTI at initiation of mechanical ventilation change with prolonged mechanical ventilation, and if they remain associated with VA-LRTI risk.

Methods

We developed a cohort of 83 subjects admitted to a long-term acute care hospital due to their prolonged dependence on mechanical ventilation; performed dense, longitudinal sampling of the lower res

SUBMITTER: Harrigan JJ 

PROVIDER: S-EPMC9630883 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature