Spalt and disco define the dorsal-ventral neuroepithelial compartments of the developing Drosophila medulla.

ABSTRACT: Spatial patterning of neural stem cell populations is a powerful mechanism by which to generate neuronal diversity. In the developing Drosophila medulla, the symmetrically dividing neuroepithelial cells of the outer proliferation center crescent are spatially patterned by the nonoverlapping expression of 3 transcription factors: Vsx1 in the center, Optix in the adjacent arms, and Rx in the tips. These spatial genes compartmentalize the outer proliferation center and, together with the temporal patterning of neuroblasts, act to diversify medulla neuronal fates. The observation that the dorsal and ventral halves of the outer proliferation center also grow as distinct compartments, together with the fact that a subset of neuronal types is generated from only one half of the crescent, suggests

SUBMITTER: Valentino P 

PROVIDER: S-EPMC9630984 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature