Recyclable Endogenous H₂ S Activation of Self-Assembled Nanoprobe with Controllable Biodegradation for Synergistically Enhanced Colon Cancer-Specific Therapy.

ABSTRACT: Excessive production of hydrogen sulfide (H₂ S) plays a crucial role in the progress of colon cancer. Construction of tumor-specific H₂ S-activated smart nanoplatform with controllable biodegradation is of great significance for precise and sustainable treatment of colon cancer. Herein, an endogenous H₂ S triggered Co-doped polyoxometalate (POM-Co) cluster with self-adjustable size, controlled biodegradation, and sustainable cyclic depletion of H₂ S/glutathione (GSH) is designed for synergistic enhanced tumor-specific photothermal and chemodynamic therapy. The designed POM-Co nanocluster holds H₂ S responsive "turn-on" photothermal property in colon cancer via self-assembling to form large-sized POM-CoS, enhancing the accumulation at t

SUBMITTER: Huang J 

PROVIDER: S-EPMC9631061 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature