Association of CFH and MAP1LC3B gene polymorphisms with age-related macular degeneration in a high-altitude population.

ABSTRACT:

Aim

To evaluate the association of complement factor H (CFH) and microtubule-associated protein 1 light chain 3 beta (MAP1LC3B) gene polymorphisms with the risk of age-related macular degeneration (AMD) in a high-altitude population.

Methods

The study group consisted of 172 participants with symptoms of AMD who were examined and diagnosed between January 2019 and June 2020. The control group was composed of 120 healthy individuals. Each participant was required to provide two milliliters of peripheral blood for DNA extraction. Two single nucleotide polymorphisms (SNPs) of CFH (rs1061170 and rs800292) and two SNPs of MAP1LC3B (rs8044820 and rs9903) were genotyped. The genotypes and allele frequencies of the SNPs in the study and control groups were

SUBMITTER: Guan RJ 

PROVIDER: S-EPMC9631175 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature