Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study.

ABSTRACT:

Aims

The aim is to evaluate associations of lung function impairment with risk of incident heart failure (HF).

Methods and results

Data were pooled across eight US population-based cohorts that enrolled participants from 1987 to 2004. Participants with self-reported baseline cardiovascular disease were excluded. Spirometry was used to define obstructive [forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) <0.70] or restrictive (FEV1/FVC ≥0.70, FVC <80%) lung physiology. The incident HF was defined as hospitalization or death caused by HF. In a sub-set, HF events were sub-classified as HF with reduced ejection fraction (HFrEF; EF <50%) or preserved EF (HFpEF; EF ≥50%). The Fine-Gray proportional sub-distribution hazards models were adjusted for sociodemographic f

SUBMITTER: Eckhardt CM 

PROVIDER: S-EPMC9631233 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature