Intestinal Epithelial Regeneration in Response to Ionizing Irradiation.

ABSTRACT: The intestinal epithelium consists of a single layer of cells yet contains multiple types of terminally differentiated cells, which are generated by the active proliferation of intestinal stem cells located at the bottom of intestinal crypts. However, during events of acute intestinal injury, these active intestinal stem cells undergo cell death. Gamma irradiation is a widely used colorectal cancer treatment, which, while therapeutically efficacious, has the side effect of depleting the active stem cell pool. Indeed, patients frequently experience gastrointestinal radiation syndrome while undergoing radiotherapy, in part due to active stem cell depletion. The loss of active intestinal stem cells in intestinal crypts activates a pool of typically quiescent reserve intestinal stem cells and

SUBMITTER: Orzechowska-Licari EJ 

PROVIDER: S-EPMC9631267 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature