Effect of oral antimicrobial prophylaxis on surgical site infection after elective colorectal surgery: multicentre, randomised, double blind, placebo controlled trial.

ABSTRACT:

Objective

To investigate whether oral antimicrobial prophylaxis as an adjunct to intravenous antibiotic prophylaxis reduces surgical site infections after elective colorectal surgery.

Design

Multicentre, randomised, double blind, placebo controlled trial.

Setting

11 university and non-university hospitals in France between 25 May 2016 and 8 August 2019.

Participants

926 adults scheduled for elective colorectal surgery.

Intervention

Patients were randomised to receive either a single 1 g dose of ornidazole (n=463) or placebo (n=463) orally 12 hours before surgery, in addition to intravenous antimicrobial prophylaxis before surgical incision.

Main outcome measures

The primary outcome was the proportion of patients with surgical site infection within

SUBMITTER: Futier E 

PROVIDER: S-EPMC9631300 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature