Prevention of delirium with agitation by yokukansan in older adults after cancer surgery.

ABSTRACT:

Objective

Preventing postoperative delirium with agitation is vital in the older population. We examined the preventive effect of yokukansan on postoperative delirium with agitation in older adult patients undergoing highly invasive cancer resection.

Methods

We performed a secondary per-protocol analysis of 149 patients' data from a previous clinical trial. Patients underwent scheduled yokukansan or placebo intervention 4-8 days presurgery and delirium assessment postoperatively. Delirium with agitation in patients aged ≥75 years was assessed using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and the Japanese version of the Delirium Rating Scale-Revised-98. We assessed odds ratios for yokukansan (TJ-54) compared with placebo for the manifestation

SUBMITTER: Sadahiro R 

PROVIDER: S-EPMC9631458 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature