NK cells CD56bright and CD56dim subset cytokine loss and exhaustion is associated with impaired survival in myeloma.

ABSTRACT: Natural killer (NK) cells are the key cells of the innate immune system that share many characteristics with T lymphocytes; their activation, however, is based on the integration of a range of activatory and inhibitory signals via receptors recognizing recurrent pathogen-associated molecular patterns. Two important populations of NK cells with differing functions are recognized: CD56bright and CD56dim. NK cells have the potential to recognize and kill malignant plasma cells, which offers therapeutic opportunities. We used mass cytometry to examine the phenotype and function of NK cell subsets from patients with newly diagnosed multiple myeloma (NDMM). We show that NK cells in NDMM are shifted toward a CD56bright but dysfunctional cytotoxic phenotype, which exhibits selective loss of cytoki

SUBMITTER: Seymour F 

PROVIDER: S-EPMC9631618 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature