Application of a semi-automated dicentric scoring system in triage and monitoring occupational radiation exposure.

ABSTRACT: The dicentric chromosome assay (DCA) is considered the gold standard for radiation biodosimetry, but it is limited by its long dicentric scoring time and need for skilled scorers. The automation of scoring dicentrics has been considered a strategy to overcome the constraints of DCA. However, the studies on automated scoring methods are limited compared to those on conventional manual DCA. Our study aims to assess the performance of a semi-automated scoring method for DCA using ex vivo and in vivo irradiated samples. Dose estimations of 39 blind samples irradiated ex vivo and 35 industrial radiographers occupationally exposed in vivo were estimated using the manual and semi-automated scoring methods and subsequently compared. The semi-automated scoring method, wh

SUBMITTER: Lee Y 

PROVIDER: S-EPMC9631783 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature