Obesity, rather than high fat diet, exacerbates the outcome of influenza virus infection in influenza-sensitized mice.

ABSTRACT:

Introduction

Obesity is associated with impaired immune function and increased susceptibility to infection. High fat (HF) diet-induced obesity is a commonly used animal model. However, HF diet itself is known to affect immune function and infection. Thus, it is not discernable which one, HF diet or adiposity, is the major contributor to the observed impairment in immunity and susceptibility to infection in HF diet-induced obesity. We hypothesized that obesity is a major contributor to impaired immune function.

Methods and results

Weight-matched outbred female CD-1 mice (1-mo) were randomly assigned to either a HF (45%) or a low fat (LF, 10%) diet group. Ten week after feeding their respective diets, weight gain in the mice fed the HF diet varied greatly. Thus, based on the a

SUBMITTER: Guo W 

PROVIDER: S-EPMC9631825 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature