A Systematic Review of the Spectrum and Prevalence of Non-Motor Symptoms in Adults with Hereditary Cerebellar Ataxias.

ABSTRACT:

Background

Cerebellar ataxias comprise a large group of heterogeneous disorders with both motor and non-motor symptoms (NMS).

Objective

We wanted to ascertain the reported prevalence of NMS in different subtypes of hereditary cerebellar ataxias.

Methods

Systematic review of studies of hereditary cerebellar ataxias (involving >5 patients) who were assessed for NMS, published in the English literature in PUBMED and EMBASE databases from 1947 to 2021.

Results

A total of 35 papers, with data from 1311 autosomal dominant spinocerebellar ataxia (SCA), 893 autosomal recessive cerebellar ataxia (ARCA), and 53 X-linked ataxia cases were included with a total of 450 controls. Mean age for SCA cases at diagnosis was 47.6 (SD, 14.9) years, for ARCA cases was 34.6 (SD, 14.7

SUBMITTER: Malek N 

PROVIDER: S-EPMC9631846 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature