The effect of vitamin B supplementation on neuronal injury in people living with HIV: a randomized controlled trial.

ABSTRACT: Effective antiretroviral therapy has radically changed the course of the HIV pandemic. However, despite efficient therapy, milder forms of neurocognitive symptoms are still present in people living with HIV. Plasma homocysteine is a marker of vitamin B deficiency and has been associated with cognitive impairment. People living with HIV have higher homocysteine concentrations than HIV-negative controls, and we have previously found an association between plasma homocysteine concentration and CSF concentration of neurofilament light protein, a sensitive marker for ongoing neuronal injury in HIV. This prompted us to perform this randomized controlled trial, to evaluate the effect of vitamin B supplementation on neuronal injury in a cohort of people living with HIV on stable antiretroviral the

SUBMITTER: Tyrberg E 

PROVIDER: S-EPMC9631976 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature