Blood-based lipidomic signature of severe obstructive sleep apnoea in Alzheimer's disease.

ABSTRACT:

Background

Obstructive sleep apnoea (OSA) is the most frequent form of sleep-disordered breathing in patients with Alzheimer's disease (AD). Available evidence demonstrates that both conditions are independently associated with alterations in lipid metabolism. However, it is unknown whether the expression of lipids is different between AD patients with and without severe OSA. In this context, we examined the plasma lipidome of patients with suspected OSA, aiming to identify potential diagnostic biomarkers and to provide insights into the pathophysiological mechanisms underlying the disease.

Methods

The study included 103 consecutive patients from the memory unit of our institution with a diagnosis of AD. The individuals were subjected to overnight polysomnography (PSG) to di

SUBMITTER: Dakterzada F 

PROVIDER: S-EPMC9632042 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature