The relationship of genetic risk score with cardiometabolic risk factors: a cross-sectional study.

ABSTRACT:

Background & aims

For more than eight decades, cardiovascular disease (CVD) has remained the leading cause of death in the world. CVD risk factors are multifaceted, with genetics and lifestyle both playing a role. The aim of this study was to investigate the association between a genetic profile risk score for obesity GRS and cardio-metabolic risk factors in overweight and obese women.

Methods

The current cross-sectional study was conducted on 391 overweight and obese women. The genetic risk score was created by combining three single nucleotide polymorphisms [MC4R (rs17782313), CAV-1 (rs3807992), and Cry-1 (rs2287161)]. Anthropometric measurements, blood pressure, and some blood parameters were measured by standard protocols.

Results

A significant association between

SUBMITTER: Gholami F 

PROVIDER: S-EPMC9632045 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature