Dual-targeting nanozyme for tumor activatable photo-chemodynamic theranostics.

ABSTRACT: Tumor phototheranostics holds a great promise on account of its high spatiotemporal resolution, tumor-specificity, and noninvasiveness. However, physical limitation of light penetration and "always on" properties of conventional photothermal-conversion agents usually cause difficulty in accurate diagnosis and completely elimination of tumor. Meanwhile, nanozymes mediated Fenton reactions can well utilize the tumor microenvironment (TME) to generate hydroxyl radicals for chemodynamic therapy (CDT), but limited by the concentration of H₂O₂ in TME and the delivery efficiency of nanozymes. To overcome these problems, a dual-targeting nanozyme (FTRNPs) is developed for tumor-specific in situ theranostics, based upon the assembling of ultrasmall Fe₃O₄

SUBMITTER: Chen C 

PROVIDER: S-EPMC9632160 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature