Nutritional modulation of the gut microbiome in allogeneic hematopoietic stem cell transplantation recipients.

ABSTRACT: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents a potentially curative strategy for many oncological and non-oncological diseases, but it is associated with marked morbidity and mortality. The disruption of gut microbiota (GM) eubiosis has been linked to major allo-HSCT complications, including infections and acute graft vs. host disease (aGvHD), and correlates with mortality. This increasing knowledge on the role of the GM in the allo-HSCT procedure has led to fascinating ideas for modulating the intestinal ecosystem in order to improve clinical outcomes. Nutritional strategies, either by changing the route of nutritional supplementation or by administering specific molecules, are increasingly being considered as cost- and risk-effective methods of modulating the

SUBMITTER: Muratore E 

PROVIDER: S-EPMC9632163 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature