Identifying tumor immunity-associated molecular features in liver hepatocellular carcinoma by multi-omics analysis.

ABSTRACT: Background: Although current immunotherapies have achieved some successes for hepatocellular carcinoma (HCC) patients, their benefits are limited for most HCC patients. Therefore, the identification of biomarkers for promoting immunotherapeutic responses in HCC is urgently needed. Methods: Using the TCGA HCC cohort, we investigated correlations of various molecular features with antitumor immune signatures (CD8⁺ T cell infiltration and cytolytic activity) and an immunosuppressive signature (PD-L1 expression) in HCC. These molecular features included mRNAs, microRNAs (miRNAs), long non-coding RNAs (lncRNAs), proteins, and pathways. Results: We found that the mutations of several oncogenes and tumor suppressor genes significantly correlated with reduced antitu

SUBMITTER: Shen Q 

PROVIDER: S-EPMC9632276 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature