Phosphogluconate dehydrogenase is a predictive biomarker for immunotherapy in hepatocellular carcinoma.

ABSTRACT:

Background

Phosphogluconate dehydrogenase (PGD) is involved in the regulation of various tumors. However, its role in hepatocellular carcinoma (HCC) is poorly understood. This study tried to determine the prognostic efficacy of PGD and its value for immunotherapy in HCC.

Methods

The data from the TCGA database was used to explore the predictive power of PGD expression and methylation on the overall survival (OS) of HCC through Cox regression and the Kaplan-Meier analysis. Then, we used the GEO and ICGC database to further verify the predictive power. Finally, the relationship between PGD and immune cells and the relationship between PGD and the efficacy of immunotherapy were explored through bioinformatics analysis in HCC.

Results

PGD is highly expressed in HCC tissue

SUBMITTER: Liu T 

PROVIDER: S-EPMC9632284 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature