Atypical Femur Fracture Risk versus Fragility Fracture Prevention with Bisphosphonates.

ABSTRACT:

Background

Bisphosphonates are effective in reducing hip and osteoporotic fractures. However, concerns about atypical femur fractures have contributed to substantially decreased bisphosphonate use, and the incidence of hip fractures may be increasing. Important uncertainties remain regarding the association between atypical femur fractures and bisphosphonates and other risk factors.

Methods

We studied women 50 years of age or older who were receiving bisphosphonates and who were enrolled in the Kaiser Permanente Southern California health care system; women were followed from January 1, 2007, to November 30, 2017. The primary outcome was atypical femur fracture. Data on risk factors, including bisphosphonate use, were obtained from electronic health records. Fractures were r

SUBMITTER: Black DM 

PROVIDER: S-EPMC9632334 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature