Biomarkers of Response and Resistance to Palbociclib Plus Letrozole in Patients With ER⁺/HER2^- Breast Cancer.

ABSTRACT:

Purpose

To determine (i) the relationship between candidate biomarkers of the antiproliferative (Ki67) response to letrozole and palbociclib alone and combined in ER⁺/HER2^- breast cancer; and (ii) the pharmacodynamic effect of the agents on the biomarkers.

Experimental design

307 postmenopausal women with ER⁺/HER2^- primary breast cancer were randomly assigned to neoadjuvant treatment with letrozole for 14 weeks; letrozole for 2 weeks, then letrozole+palbociclib to 14 weeks; palbociclib for 2 weeks, then letrozole+palbociclib to 14 weeks; or letrozole+palbociclib for 14 weeks. Biopsies were taken at baseline, 2 and 14 weeks and surgery at varying times after stopping palbociclib. Immunohistochemical analyses were conducted for Ki67,

SUBMITTER: Dowsett M 

PROVIDER: S-EPMC9632606 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature