One-pot synthesis of polycyclic isoindolines using isoindole umpolung.

ABSTRACT: Using an isoindole umpolung strategy, a one-pot synthesis of polycyclic isoindolines was accomplished. In this reaction, the in situ-generated nucleophilic isoindoles were converted to electrophilic isoindoliums via protonation, which underwent a Pictet-Spengler-type cyclization to afford a variety of polycyclic isoindolines in good yields.

SUBMITTER: Weintraub RA 

PROVIDER: S-EPMC9632635 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature