Linear and non-linear Mendelian randomization analyses of sex-specific associations between sleep duration and hyperuricemia.

ABSTRACT:

Background

Observational studies have suggested a potential non-linear association between sleep duration and hyperuricemia. However, the causal nature and sex-specific differences are poorly understood. We aimed to determine the shape of sex-specific causal associations between sleep duration and hyperuricemia in the UK Biobank.

Methods

Logistic regression was used to investigate the observational association between self-reported sleep duration and hyperuricemia among 387,980 white British participants (mean age: 56.9 years and 46.0% males). Linear and non-linear Mendelian Randomization (MR) analyses were performed to assess the causal association between continuous sleep duration and hyperuricemia. The causal effects of genetically predicted short (<7 h) and long (>8 h) s

SUBMITTER: Zou C 

PROVIDER: S-EPMC9632753 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature