Reporting quality in preclinical animal experimental research in 2009 and 2018: A nationwide systematic investigation.

ABSTRACT: Lack of translation and irreproducibility challenge preclinical animal research. Insufficient reporting methodologies to safeguard study quality is part of the reason. This nationwide study investigates the reporting prevalence of these methodologies and scrutinizes the reported information's level of detail. Publications were from two time periods to convey any reporting progress and had at least one author affiliated to a Danish University. We retrieved all relevant animal experimental studies using a predefined research protocol and a systematic search. A random sampling of 250 studies from 2009 and 2018 led to 500 publications in total. Reporting of measures known to impact study results estimates were assessed. Part I discloses a simplified two-level scoring "yes/no" to identify the p

SUBMITTER: Kousholt BS 

PROVIDER: S-EPMC9632797 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature