Comprehensive transcriptomic analysis of immune-related eRNAs associated with prognosis and immune microenvironment in melanoma.

ABSTRACT:

Background

Recent evidence suggests that enhancer RNAs (eRNAs) play key roles in cancers. Identification of immune-related eRNAs (ireRNAs) in melanoma can provide novel insights into the mechanisms underlying its genesis and progression, along with potential therapeutic targets.

Aim

To establish an ireRNA-related prognostic signature for melanoma and identify potential drug candidates.

Methods

The ireRNAs associated with the overall survival (OS-ireRNAs) of melanoma patients were screened using data from The Cancer Genome Atlas (TCGA) via WGCNA and univariate Cox analysis. A prognostic signature based on these OS-ireRNAs was then constructed by performing the least absolute shrinkage and selection operator (LASSO) Cox regression analysis. The immune landscape a

SUBMITTER: Gan Y 

PROVIDER: S-EPMC9632973 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature