The composition of the gut microbiota is altered in biliary atresia with cholangitis.

ABSTRACT:

Aim

To detect the composition of the gut microbiota in biliary atresia after Kasai surgery.

Methods

Infants within six months after the Kasai operation who were diagnosed by cholangiography at Shanghai Children's Hospital were enrolled in the study. Fecal samples were collected from diapers, placed into sterile tubes in the inpatient department or outpatient department and frozen at -80°C within half an hour. The gut microbiota was detected by 16S rRNA sequences. Then, the patients that were followed up to one year after the Kasai operation who suffered from cholangitis at least one time were grouped into the BAcho group, and the others were grouped into the BAnoncho group.

Results

Nine of 18 BA patients were grouped into the BAcho group, and the others were grouped i

SUBMITTER: Zheng L 

PROVIDER: S-EPMC9632985 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature