Early life stressful experiences escalate aggressive behavior in adulthood via changes in transthyretin expression and function.

ABSTRACT: Escalated and inappropriate levels of aggressive behavior referred to as pathological in psychiatry can lead to violent outcomes with detrimental impact on health and society. Early life stressful experiences might increase the risk of developing pathological aggressive behavior in adulthood, though molecular mechanisms remain elusive. Here, we provide prefrontal cortex and hypothalamus specific transcriptome profiles of peripubertal stress (PPS) exposed Balb/c adult male mice exhibiting escalated aggression and adult female mice resilient to such aberrant behavioral responses. We identify transthyretin (TTR), a well known thyroid hormone transporter, as a key regulator of PPS induced escalated aggressive behavior in males. Brain-region-specific long-term changes in Ttr gene express

SUBMITTER: Rawat RS 

PROVIDER: S-EPMC9633068 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature