Modular Synthesis of Peptide-Based Single- and Multimodal Targeted Molecular Imaging Agents.

ABSTRACT: A practical, modular synthesis of targeted molecular imaging agents (TMIAs) containing near-infrared dyes for optical molecular imaging (OMI) or chelated metals for magnetic resonance imaging (MRI) and single-photon emission correlation tomography (SPECT) or positron emission tomography (PET) has been developed. In the method, imaging modules are formed early in the synthesis by attaching imaging agents to the side chain of protected lysines. These modules may be assembled to provide a given set of single- or dual-modal imaging agents, which may be conjugated in the last steps of the synthesis under mild conditions to linkers and targeting groups. A key discovery was the ability of a metal such as gadolinium, useful in MRI, to serve as a protecting group for the chelator, 1,4,7,10-tetraaza

SUBMITTER: Schmitthenner HF 

PROVIDER: S-EPMC9633131 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature