Fatty acid metabolism predicts prognosis and NK cell immunosurveillance of acute myeloid leukemia patients.

ABSTRACT:

Background

Cell metabolic reprogramming is a hallmark of tumor prognosis, and fatty acid metabolism (FAM) plays a crucial role in the tumor microenvironment (TME). However, the relationship between FAM, TME, and prognosis of acute myeloid leukemia (AML) patients remains elusive.

Methods

We extracted the single-cell RNA sequencing (scRNA-Seq) and bulk transcriptome data of AML patients from the TCGA and GEO databases and assessed the relationship between FAM, TME, and AML patient prognosis. We also performed functional enrichment (FE) assay to evaluate the significance of FAM in anti-AML immunosurveillance.

Results

Our scRNA-Seq analysis revealed that the leukemic stem cell (LSC)-enriched population exhibited elevated levels of FAM-related genes. Using these FAM-relate

SUBMITTER: Ye Z 

PROVIDER: S-EPMC9633260 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature