Clinical significance and immune landscape of KIR2DL4 and the senescence-based signature in cutaneous melanoma.

ABSTRACT: Senescence is an effective barrier to tumor progression. Mutations that inhibit senescence and promote cell division are mandatory for the development of cancer. Therefore, it is particularly important to explore the differences between cutaneous melanoma (CM) patients with severe and mild degrees of senescence. We clustered all the patients with CM in the Cancer Genome Atlas (TCGA) database based on all the genes of the senescence pathway in the CellAge and MSigDB database. The prognosis, immunotherapy effect, tumor microenvironment score, NRAS mutation rate, expression of CD274, CTLA4, and PDCD1, and abundance of CD8⁺ T and natural killer (NK) cell infiltration in the younger group of patients (YG) were higher than those in the older group (OG). Compared with the American Join

SUBMITTER: Mao R 

PROVIDER: S-EPMC9633315 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature