Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation.

ABSTRACT:

Objective

Mental disorders are heritable and polygenic, and genome-wide genetic correlations (r_g) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, r_g may underestimate the shared genetic underpinnings of mental disorders and related traits because it does not differentiate mixtures of concordant and discordant genetic effects from an absence of genetic overlap. Using novel statistical genetics tools, the authors aimed to evaluate the genetic overlap between mental disorders and related traits when accounting for mixed effect directions.

Methods

The authors applied the bivariate causal mixture model (MiXeR) to summary statistics for four mental disor

SUBMITTER: Hindley G 

PROVIDER: S-EPMC9633354 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature