Exploring pharmacological inhibition of G_q/11 as an analgesic strategy.

ABSTRACT:

Background and purpose

Misuse of opioids has greatly affected our society. One potential solution is to develop analgesics that act at targets other than opioid receptors. These can be used either as stand-alone therapeutics or to improve the safety profile of opioid drugs. Previous research showed that activation of G_q/11 proteins by G-protein coupled receptors has pro-nociceptive properties, suggesting that blockade of G_q/11 signalling could be beneficial for pain control. The aim of this study was to test this hypothesis pharmacologically by using potent and selective G_q/11 inhibitor YM-254890.

Experimental approach

We used a series of behavioural assays to evaluate the acute responses of mice to painful thermal stimulation while administe

SUBMITTER: Marwari S 

PROVIDER: S-EPMC9633401 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature