Formulation Excipients and Their Role in Insulin Stability and Association State in Formulation.

ABSTRACT: While  excipients are often overlooked as the "inactive" ingredients in pharmaceutical formulations, they often play a critical role in protein stability and absorption kinetics. Recent work has identified an ultrafast absorbing insulin formulation that is the result of excipient modifications. Specifically, the insulin monomer can be isolated by replacing zinc and the phenolic preservative metacresol with phenoxyethanol as an antimicrobial agent and an amphiphilic acrylamide copolymer excipient for stability. A greater understanding is needed of the interplay between excipients, insulin association state, and stability in order to optimize this formulation. Here, we formulated insulin with different preservatives and stabilizing excipient concentrations using both insulin lispro and regul

SUBMITTER: Maikawa CL 

PROVIDER: S-EPMC9633423 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature