Treatment-related thoracic soft tissue sarcomas in US breast cancer survivors: a retrospective cohort study.

ABSTRACT:

Background

Soft tissue sarcoma is a rare but serious side-effect of radiotherapy to treat breast cancer, and rates are increasing in the USA. We evaluated potential co-factors in two complimentary cohorts of US breast cancer survivors.

Methods

In this retrospective cohort study, we sourced data from the Kaiser Permanente (KP) cohort and the Surveillance, Epidemiology, and End Results (SEER) 13 registries cohort, both in the USA. The KP cohort included 15 940 women diagnosed with breast cancer from Jan 1, 1990, to Dec 31, 2016, in KP Colorado, KP Northwest (which serves Oregon and Southwest Washington state), or KP Washington, with detailed treatment data and comorbidities (including hypertension and diabetes at or before breast cancer diagnosis) from electronic medical recor

SUBMITTER: Veiga LHS 

PROVIDER: S-EPMC9633446 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature