Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice.

ABSTRACT: Autoimmune disorders such as type 1 diabetes (T1D) are believed to be caused by the interplay between several genetic and environmental factors. Elucidation of the role of environmental factors in metabolic and immune dysfunction leading to autoimmune disease is not yet well characterized. Here we investigated the impact of exposure to a mixture of persistent organic pollutants (POPs) on the metabolome in non-obese diabetic (NOD) mice, an experimental model of T1D. The mixture contained organochlorides, organobromides, and per- and polyfluoroalkyl substances (PFAS). Analysis of molecular lipids (lipidomics) and bile acids in serum samples was performed by UPLC-Q-TOF/MS, while polar metabolites were analyzed by GC-Q-TOF/MS. Experimental exposure to the POP mixture in these mice led to sever

SUBMITTER: Sinioja T 

PROVIDER: S-EPMC9633531 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature