Intrinsic subtypes in Ethiopian breast cancer patient.

ABSTRACT:

Purpose

The recent development of multi-gene assays for gene expression profiling has contributed significantly to the understanding of the clinically and biologically heterogeneous breast cancer (BC) disease. PAM50 is one of these assays used to stratify BC patients and individualize treatment. The present study was conducted to characterize PAM50-based intrinsic subtypes among Ethiopian BC patients.

Patients and methods

Formalin-fixed paraffin-embedded tissues were collected from 334 BC patients who attended five different Ethiopian health facilities. All samples were assessed using the PAM50 algorithm for intrinsic subtyping.

Results

The tumor samples were classified into PAM50 intrinsic subtypes as follows: 104 samples (31.1%) were luminal A, 91 samples (27.2%) we

SUBMITTER: Desalegn Z 

PROVIDER: S-EPMC9633534 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature