Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia.

ABSTRACT: Bioinspired microrobots capable of actively moving in biological fluids have attracted considerable attention for biomedical applications because of their unique dynamic features that are otherwise difficult to achieve by their static counterparts. Here we use click chemistry to attach antibiotic-loaded neutrophil membrane-coated polymeric nanoparticles to natural microalgae, thus creating hybrid microrobots for the active delivery of antibiotics in the lungs in vivo. The microrobots show fast speed (>110 µm s^-1) in simulated lung fluid and uniform distribution into deep lung tissues, low clearance by alveolar macrophages and superb tissue retention time (>2 days) after intratracheal administration to test animals. In a mouse model of acute Pseudomonas aeruginosa pneumonia, the

SUBMITTER: Zhang F 

PROVIDER: S-EPMC9633541 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature