Population pharmacokinetics of ethambutol in African children: a pooled analysis.

ABSTRACT:

Objectives

Ethambutol protects against the development of resistance to co-administered drugs in the intensive phase of first-line anti-TB treatment in children. It is especially relevant in settings with a high prevalence of HIV or isoniazid resistance. We describe the population pharmacokinetics of ethambutol in children with TB to guide dosing in this population.

Methods

We pooled data from 188 intensively sampled children from the DATiC, DNDi and SHINE studies, who received 15-25 mg/kg ethambutol daily according to WHO guidelines. The median (range) age and weight of the cohort were 1.9 (0.3-12.6) years and 9.6 (3.9-34.5) kg, respectively. Children with HIV (HIV+; n = 103) received ART (lopinavir/ritonavir in 92%).

Results

Ethambutol pharmacokinetics were best des

SUBMITTER: Tikiso T 

PROVIDER: S-EPMC9633720 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature