HLA Zygosity Increases Risk of Hepatitis B Virus-Associated Hepatocellular Carcinoma.

ABSTRACT:

Background

Diversity in the HLA genes might be associated with disease outcomes-the heterozygote advantage hypothesis. We tested this hypothesis in relation to hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC).

Methods

We utilized DNA from > 10 000 Taiwanese individuals with current or past HBV infection to examine the association between HLA diversity and critical natural history steps in the progression from HBV infection to HCC. Individuals were classified as homozygotes at a given locus when imputed to carry the same 4-digit allele for the 2 HLA alleles at that locus.

Results

Increase in number of homozygous HLA class II loci was associated with an increased risk of chronic HBV infection (Ptrend = 1.18 × 10-7). Among chronic HBV carriers, increase

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9633721 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature