Sex-specific biomarkers in Alzheimer's disease progression: Framingham Heart Study.

ABSTRACT:

Background

Sex differences in Alzheimer's disease (AD) are not well understood.

Methods

We performed sex-specific analyses of AD and annualized cognitive decline with clinical and blood biomarker data in participants 60+ years old in the community-based longitudinal Framingham Heart Study Offspring Cohort (n = 1398, mean age 68 years, 55% women).

Results

During 11 years of follow-up, women were 96% more likely than men to be diagnosed with clinical AD dementia after adjusting for age and education in the younger age group 60 to 70 years (n = 946; 95% confidence interval [CI], 1.08 to 3.56) although not in the older age group (70+) (n = 452; hazard ratio = 0.98; 95% CI, 0.68 to 1.53). Sex-differences in incident AD rates decreased with increasing l

SUBMITTER: Liu C 

PROVIDER: S-EPMC9633867 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature